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Perspective of the Induction of Liver Microsomal P450s by Chemical Compounds
Tsuneo Omura

Drug Metabolism and Disposition May 3, 2022, DMD-COM-2022-000891; DOI: https://doi.org/10.1124/dmd.122.000891
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Metabolism and Disposition of [¹⁴C]Pevonedistat, a First-In-Class NEDD8‑Activating Enzyme Inhibitor, After Intravenous Infusion to Patients With Advanced Solid Tumors
Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2022-000842; DOI: https://doi.org/10.1124/dmd.122.000842
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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)
Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis and Patrick T. Ronaldson

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000781; DOI: https://doi.org/10.1124/dmd.121.000781
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Understanding Inter-individual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-limited Multi-compartment Liver Model in a Population Based PBPK Framework
Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Bois and Masoud Jamei

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000818; DOI: https://doi.org/10.1124/dmd.121.000818
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The hydroxylation position rather than chirality determines how efavirenz metabolites activate CYP46A1 in vitro
Natalia Mast, Anna Fotinich and Irina A. Pikuleva

Drug Metabolism and Disposition April 29, 2022, DMD-AR-2022-000874; DOI: https://doi.org/10.1124/dmd.122.000874
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Selection of an optimal in vitro model to assess P-gp inhibition: comparison of vesicular and bi-directional transcellular transport inhibition assays
Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan Chu

Drug Metabolism and Disposition April 29, 2022, DMD-AR-2021-000807; DOI: https://doi.org/10.1124/dmd.121.000807

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DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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